人間の探究心、知的好奇心は尽きることがないようです。
Dan Shechtman, Nobel Laureate in Chemistry 2011, at the microscope.
Discover Hidden Worlds
From
cells to bacteria to single molecules and atoms, microscopes help us
explore worlds beyond the naked eye. Microscopes are invaluable tools in
research and education. They are used in a wide range of scientific
fields and many major discoveries in biology, medicine and materials
research were made possible through advances in microscopy techniques.
In 'Microscopes' you can learn more about different microscopes and what
scientists study with them as well as try out some of the Nobel Prize
awarded techniques by using the microscope simulators.
Explore 'Microscopes'
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Physics Laureate Fritz Zernike.
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Thrilling Toy and Important Tool
Already
in 1590, the first optical microscope - two lenses in a tube - was
developed, although it is hard to identify the original inventors.
Technical improvements during the following centuries made microscopy
very popular among the scientists. In 1903, Richard Zsigmondy developed
the ultra microscope that made it possible to study objects below the
wavelength of light. He was awarded the 1925 Nobel Prize in Physics.
Another
improvement was made by Fritz Zernike in the 1930s, when he invented a
microscope where light phase content enhanced the image contrast. In
1953, he was awarded the Physics Prize for the phase-contrast
microscope, allowing studies of colorless and transparent biological
materials.
Watch Professor Zernike receiving the telegram notifying him about the Nobel Prize
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Two Radical Leaps
The
1986 Nobel Prize for Physics rewarded three scientists for two radical
leaps in microscope technology that finally allowed us to witness life
at the atomic level. In 1933, Ernst Ruska, one of the three Laureates,
designed and built the first electron microscope. The ability to use
electrons in microscopy greatly improved the resolution and greatly
expanded the borders of exploration.
Read more about Ernst Ruska's way to the Nobel Prize
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Detail from the first electron microscope. Source: Deutsches Museum. Photo: J. Brew. CC BY-SA 3.0 via Wikimedia Commons.
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"Luck Was on Our Side"
Gerd
Binnig and Heinrich Rohrer, the other two Laureates sharing the 1986
Physics Prize, succeeded in designing a scanning tunneling microscope
that gave three-dimensional images of objects down to the atomic level.
There were enormous experimental difficulties involved in building an
instrument of the precision and stability required, and maybe also some
luck.
Heinrich Rohrer talks about the need of luck
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"People Often Ask What Is the Use of It"
1982
Chemistry Laureate Aaron Klug was awarded for developing the
crystallographic electron microscopy, an important tool for determining
the chemical structure of complicated components in living organisms. In
his speech at the Nobel Banquet, Aaron Klug emphasized the importance
of basic science.
Read Aaron Klug's speech at the Nobel Banquet
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Chemistry Laureate Aaron Klug.
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STED
microscopy image (inset) provides appr. ten times sharper details
compared to a conventional light microscope (outer image).
© G. Donnert, S. W. Hell.
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They Brought Optical Microscopy into the Nanodimension
For
a long time optical microscopy was held back by a presumed limitation:
that it would never obtain a better resolution than half the wavelength
of light. Helped by fluorescent molecules the most recent Chemistry
Laureates, Eric Betzig, Stefan W. Hell and William E. Moerner,
ingeniously circumvented this limitation.
Watch a short explanation of the 2014 Chemistry Prize
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Monthly Quiz
An Epoch-Making Discovery
At
the end of the 19th century, a country doctor discovered the bacteria
causing tuberculosis using a microscope. What was his name? Make a guess
and click to submit your answer.
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